Volume 6, Issue 4, December 2018, Page: 49-54
A Study of Ultrasonography Diagnosis of Non-Alcoholic Fatty Liver and Its Correlation with Obesity, Diabetes and Other Risk Factors
Mwahib Aldosh, Radiological Science Department, Applied Medical College, Najran University, Najran, Kingdom of Saudi Arabia
Received: Dec. 18, 2018;       Accepted: Jan. 5, 2019;       Published: Jan. 28, 2019
DOI: 10.11648/j.ijmi.20180604.13      View  23      Downloads  15
Abstract
Objective: Non-Alcoholic Fatty Liver Disease (NAFLD) is a major hepatic problem in a modern –day, which, refer to a group of conditions where there is accumulation of steatosis in the liver of nonalcoholic people. It is a very common disorder which often asymptomatic. And may associated with many risk factors such as diabetes obesity and other factors. Therefore this study was conducted to determine the correlation between NAFLD and above mentioned condition using ultrasonography investigation, because that the relation of non-alcoholic fatty liver disease to these factors are not fully understood. Methods: A total of 250 Sudanese participants screening by abdominal ultrasound were used as the population of this cross-sectional prospective study, 50 out of them diagnosed with NAFLD represented the study sample. The data of the study were obtained in Sudan –Khartoum city in period from July to September 2018. Results data was analyzed to find out the correlation between NAFLD with diabetes, obesity and some other risk factors such as hypertension, elevation of cholesterol level and patient physical activities and participants were included if they didn’t have alcohol intake and their age is 20 years old and above. Statistical descriptive analysis using (SPSS) statistical package for the social sciences program was used to determine the frequency distribution of demographic variables in tables and graphs. Results: The total prevalence result of NAFLD among study population sample achieved 20% percentage and in comparing results of the total number of male and female, the gender distribution reflect that the higher percentage of fatty liver presence in male with (56.00%) percentage more than female with (44.00%) of the study sample, corresponded to maximum age range (40-49) years of group aging in the general sample of the study. Regarding to histologic and/or clinical markers of the study samples, incidence of diabetes, were (40%) with NAFLD and in correlate with patient gender, most of the diabetics are female with (22%) detection. Results for correlation of NAFLD and obesity achieved 78% detection of total study samples. Others Ultrasound results, found that there are correlation with NAFLD and many other risk factors including hypertension, elevation of cholesterol level and patient physical activity. Conclusion: Association with Nonalcoholic fatty liver disease (NAFLD) with obesity, diabetes in addition to hypertension, elevation of cholesterol level and type of patient activities as have been detected in the recent study, these findings should be taken into consideration when patient counseling and monitoring.
Keywords
NAFLD, Obesity, Diabetes, Risk Factors, Ultrasound
To cite this article
Mwahib Aldosh, A Study of Ultrasonography Diagnosis of Non-Alcoholic Fatty Liver and Its Correlation with Obesity, Diabetes and Other Risk Factors, International Journal of Medical Imaging. Vol. 6, No. 4, 2018, pp. 49-54. doi: 10.11648/j.ijmi.20180604.13
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M Hepatology. 2016 Jul: 64(1):73-84.
[2]
American liver foundation, Liver disease communities, Available at https://liverfoundation.org access September 2018.
[3]
Al Rifai M, Silverman MG, Nasir K, Budoff MJ, et, al, The association of nonalcoholic fatty liver disease, obesity, and metabolic syndrome, with systemic inflammation and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis( MESA). 2015 Apr; 239(2):629-33.
[4]
Youssi ZM, Otgonsuren M, Venkatesan C, Mishra A, In patients with non-alcoholic fatty liver disease, metabolically abnormal individuals are at a higher risk for mortally while metabolically normal individuals are not. Metabolism. 2013 Mar; 62(3):352-60
[5]
Chalasani N, Younossi Z, Lavine JE, et al, The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the America Association for the study of liver Diseases, Hepatology. 2018; 67(1):328. Epub 2017 Sep 29.
[6]
Kumarendran B, O’Reilly MW, Manolopuolos KN, et, al. Polycystic ovary syndrome, androgen excess, and the risk of nonalcoholic fatty liver disease in women: A longitudinal study based on a United kingdom primary care database, PLoS Med. 2018;15(3):e1002542. Epub 2018 Mar 28.
[7]
European Association for the Study of the liver (EASL), European Association for the Study of Disease (EASD), European Association for the study of Obesity (EASO), EASL-EASD-EASO Clinical practice Guidelines for the management of non-alcoholic fatty liver disease., J Hepatol. 2016; 64(6):1388. Epud 2016 Apr 7.
[8]
Ma. J, Hwang SJ, Pedley A, et, al. Bi- directional analysis between fatty liver and cardiovascular disease risk factors. J Hepatol. 2017; 66(2):390. Epub 2016 OCT 10.
[9]
Milić S, Stimac D. Nonalcoholic fatty liver disease/steatohepatitis epidemiology, pathogenesis, clinical presentation and treatment. Dig Dis 2012; 30: 158-162[PMID:22722431 DOI: 10.1159/000336669.
[10]
Fabbrini E. Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implication Hepatology 2010:51:679-689(PMID: 20141406 DOI: 10.1002/hep.23280.
[11]
Hofer, Matthias. Ultrasound Teaching Manual. The Basics of Performer Ultrasound Scans/ Matthias Hofer: translated by peter F. Winter (1999). New York, Druckhaus Gotz, Ludwigsburg ISBN 3-13-111041-4 _ISBN 0-86577-725-X(TNY).
[12]
Susanna Ovel, RDMS, RVT, RT(R). Comprehensive review for general sonography examination 2009;978 0 323 05282 5.
[13]
Zobair M. Younossi, Aaron B. Koenig, Dinan Abdelatif, et. al, Global Epidemiology of Nonalcoholic Fatty Liver Disease – Meta-Analytic Assessment of Prevalence, Incidence, and Outcomes, HEPATOLOGY, VOL. 64, NO. 1, 2016.
[14]
Review, Abdullah Obaid Binobaid, Mohannad Abdulrazzaq Alalwan, Abdullah Hussaen A Almalk, et. al, Prevalence and risk factors of fatty liver among Adults. The Egyptian Journal of Hospital Medicine (January 2018) Vol. 70(9), page 1552-1567.
[15]
Almobarak AO, et al. Arab J Gastroenterol. Nonalcoholic Fatty liver disease (NAFLD) in a Sudanese population. Arab Journal of Gastroenterology 16(2015) 54-58.
[16]
Al-hamoudi, W., El-Sabbah, M., Ali, S., Altuwaijri M, Bedewi M, Adam M, Alhammad Alwaleed. Sanai F, Alswat K, and Abdoa A, Epidemiological, clinical, and biochemical characteristics of Saudi patients with nonalcoholic fatty liver disease: a hospital –based study, King Khalid University Hospital in Riyadh, Saudi Aradia Ann Saudi Med 2012:32(3):288-292.
[17]
Zaki ME, Ezzat W, Elhosary YA, Saleh OM. Factors Associated with Nonalcoholic Fatty Liver Disease in Obese Adolescents. Maced J Med Sci. 2013 Sep 15:6(3):273-277.
[18]
Faisal A, Elshahat M, Growda R, Alzaidi A, Ald-hawani B & Alharbi H, Cardiovascular Disease Risk Factors among Non-alcoholic Fatty Liver Disease Patients at Makkah, Kingdom of Saudi Arabia, Global Journal of Health Science: Vol. 8, No. 11:2016.
[19]
Ahmed, M. E., Khalid, N. M., Mehdar, K. M. The rate of fatty Liver Disease in Najran Patients between 20-60 years Old at King Khalid Hospital. International Journal of Science and Research (IJSR), India online ISSN: 2319-7064.2013.
Browse journals by subject