Correlation Between the Plasma Cortisol Level and the Characteristics of Magnetic Resonance Spectroscopy of the Prefrontal Cortex and Hippocampus in Depressed Patients
Yi Xu,
Zhouli Zheng,
Huiyi Deng,
Chipeng Wu,
Changzheng Shi,
Hao Xu
Issue:
Volume 4, Issue 5, September 2016
Pages:
39-43
Received:
11 July 2016
Accepted:
18 August 2016
Published:
7 September 2016
Abstract: To explore the characteristic changes of magnetic resonance spectroscopy of prefrontal cortex and hippocampus and the correlation with the plasma cortisol level in depressed patients without any therapy. Subjects were divided into groups by the Hamilton depression scale. Blood was taken to detect the plasma cortisol level. Meanwhile, subjects were scanned by MRI and 1H-MRS to test the brain structure and the levels of NAA, Cho, Cr in prefrontal cortex and hippocampus. The level of plasma cortisol, the value of MRS and 1H-MRS of the patients were compared with those of normal control. We found that the level of plasma cortisol in depression group is higher than that in normal control group (P=0.000). A negative correlation between the level of plasma cortisol and the level of NAA in the left prefrontal cortex is observed (r = -0.625, P = 0.041), while in the left hippocampus, the correlation between them is positive (r = 0.647, P = 0.043). The level of NAA in the left prefrontal cortex of depression group is lower than that of normal control (P = 0.006); and the levels of NAA, Cho, Cr in both left and right hippocampus of depression group is lower than those of normal control group (P < 0.05). These data suggest that the changes of energy metabolism may happen before the structural damage of prefrontal cortex and hippocampus, and correlate to the changes of the level of plasma cortisol in depression patients.
Abstract: To explore the characteristic changes of magnetic resonance spectroscopy of prefrontal cortex and hippocampus and the correlation with the plasma cortisol level in depressed patients without any therapy. Subjects were divided into groups by the Hamilton depression scale. Blood was taken to detect the plasma cortisol level. Meanwhile, subjects were ...
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Incidental Findings of the Lumbar Spine at MRI in Patients Diagnosed with Discopathy
Mohammad Sobhan,
Majid Samiee,
Yadollah Asgari,
Mansour Ahmadi
Issue:
Volume 4, Issue 5, September 2016
Pages:
44-47
Received:
6 August 2016
Accepted:
19 August 2016
Published:
8 September 2016
Abstract: Background and objectives: the present study is an attempt to investigate the prevalence and type of lumbar spinal MRI incidental findings in patients diagnosed with discopathy. Materials and Methods: This cross-sectional study was conducted from 26/09/2012 to 14/01/2013 on MRI findings of 444 patients clinically diagnosed with Discopathy and approved MRI reports. A Radiologist studied the MRI results in terms of single vertebral hemangioma, multiple vertebral hemangiomas, kidney cyst, liver cyst and Perineural cyst. Data were collected and analyzed through Fisher Exact test. Results: 73 patients (16%) out of a total of 444 patients (215 males (48.4%) and 229 females (51.6) with a mean age of 42 years and age range of 13 to 87 years), provided incidental findings. The frequency of single vertebral hemangioma, multiple vertebral hemangioma, kidney cysts, liver cysts and Perineural cyst was 31 cases (7.0%), 11 cases (2.5%), 13 cases (2.9%), 2 cases (0.5%) and 3 cases (0.7%) respectively. There was no significant correlation between the frequency distribution of findings in terms of sex (P-value = 0.08), but there was a significant correlation between the frequency distribution of findings in terms of age (P-value = 0.006). Conclusion: incidental findings are fairly common findings in the MRI of patients with discopathy. There is a significant correlation between the frequency distributions of these findings and the patients’ age, however, no correlation was observed between these findings and patients' sex.
Abstract: Background and objectives: the present study is an attempt to investigate the prevalence and type of lumbar spinal MRI incidental findings in patients diagnosed with discopathy. Materials and Methods: This cross-sectional study was conducted from 26/09/2012 to 14/01/2013 on MRI findings of 444 patients clinically diagnosed with Discopathy and appro...
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